Hidroclorotiazida de 25mg /1g) and theophylline (10mg/kg) (Hindmarch et al., 1991; Jang 1994). It may be of interest that several studies have also reported a dose-dependent inhibition of monoamine oxidase (MAO) activity (Peyron et al., 1992; Dreyfus 1996; Jang et al., 1994). In mice, both the 5-HT 2A antagonist ketanserin (5mg/kg) and the 5-HT 2B antagonist SB-2254867 (0.05mg/kg) were able to block the Best drugstore mascara australia MAO A-competitive inhibition of 5-hydroxytryptamine 2A (5-HT ) release; however, no effects were observed on 5-HT 2B. Similarly, when these two agents were combined, the 5-HT 2A -induced increase of 2B was blocked by the 5-HT 2B -selective antagonist SB-263478. The 5-HT 1A antagonist scopolamine (1.25mg/kg) was able to block the MAO A-competitive inhibition of 5-HT release (Klein et al., 1992; Dreyfus 1998). In a similar manner, the 5-HT 1A antagonist propranolol (5mg/kg) was also able to block the MAO A-competitive inhibition of 5-HT release (Dreyfus et al., 1998). Similarly, the 5-HT 1A antagonist prazosin (1 and 7mg/kg) was able to block the MAO A-competitive inhibition of 5-HT release (Peyron et al., 1992; Dreyfus 1998). However, the selective 5-HT 1A antagonist ketanserin (10mg/kg) and the buy teva valium online 5-HT 1B antagonist SB-2254867 (0.05mg/kg) were not able to block the MAO A -competitive inhibition of 5-HT release by either ketanserin or SB-263478 (Rosenbaum et al., 1996; Pérez-Santos 1997). However, it is important to emphasize that the mechanisms by which these drugs work are not completely understood. Some studies have shown that the 5-HT 1A antagonist ketanserin is able to increase the extracellular levels of 5-HT in rat brain, but this increase can be blocked by the 5-HT 1B agonist rimonabant (Chen et al., 1992; Tannock 1994). It is possible that the effects of ketanserin are mediated via a peripheral effect on serotonin (Rosenbaum et al., 1996). Another possible mechanism of action is the inhibition MAO with ketanserin (Rosenbaum et al., 1996). The effects of 5-HT 2A, 2B and 2C antagonists on 5-HT release have also been described, with 5-HT 2A antagonist ketanserin (1 and 7mg/kg) blocking the 5-HT 2A -induced increase of 2B and 5-HT 2C -induced increase of release. Likewise, the 5-HT 2A antagonist propranolol (5mg/kg) was able to block the 5-HT 2A -induced increase of release in rat brain. However, the 5-HT 2A antagonist SB-263478 was not able to block the 5-HT 2A -induced increase of release in rat brain (Pérez-Santos et al., 1997). Moreover, the 5-HT 2B antagonist SB-263478 was also found to block the 5-HT 2B -induced increase of release in rat brain (Pérez-Santos et al., 1997). There is also some evidence that the 5-HT 2A -selective antagonist ketanserin (10mg/kg) is able to inhibit the MAO A-competitive inhibition of 5-HT release. In mouse brain, ketanserin (10mg/kg) was able to inhibit the MAO A-competitive inhibition of 5-HT release (Jang et al., 1994). However, the 5-HT 2B -selective antagonist SB-263478 was not able to inhibit the MAO A -competitive inhibition of 5-HT release in mouse brain (Pérez-Santos et al., 1997). The 5-HT 2C antagonist SB-2254867 (0.05mg/kg) has also been shown to inhibit the MAO A-dependent inhibition of 5-HT 2C -induced increase release (Pérez-Santos et al., 1997).

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